Dr. Hsu’s research is centered on elucidating morphogenetic signaling networks in development and disease. The Hsu laboratory has developed several versatile mouse genetic models for the study of tissue-specific stem cells and niches in craniofacial morphogenesis, skeletogenesis, skin development, neural development and cancer. Current efforts focus on the interplay of evolutionary conserved signal transduction pathways essential for self-renewal and maintenance of tissue-specific stem cells and their expansion, fate determination and differentiation. By elucidating these genetic regulatory mechanisms, the lab hopes to advance the knowledge base of human diseases, leading to strategic improvement for molecular and regenerative medicine.
Takamitsu Maruyama, Ming Jiang and Wei Hsu. Gpr177, a novel locus for bone-mineral-density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. Journal of Bone and Mineral Research. 2013 May;28(5):1150-9.
Jiang Fu and Wei Hsu. Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. Journal of Investigative Dermatology. 2013 Apr;133(4):890-8.
Ming Jiang, Shang-Yi Chiu and Wei Hsu (2011). SUMO-specific protease 2 in Mdm2-mediated regulation of p53. Cell Death and Differentiation. 18, 1005-1015.
Takamitsu Maruyama, Anthony J Mirando, Chu-Xia Deng and Wei Hsu (2010). The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. Science Signaling. 3, ra40.
Jiang Fu, Ming Jiang, Anthony J Mirando, H-M Ivy Yu and Wei Hsu (2009). Reciprocal regulation of Wnt and Gpr177/mouse Wntless is essential for embryonic axis formation. Proc Natl Acad Sci USA. 106, 185998-18603.
Shang-Yi Chiu, Nagoya Asai, Frank Costantini and Wei Hsu (2008). SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLOS Biology. 6(12): e310.