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Wendy J. Huss

Wendy J.
Assistant Professor
Roswell Park Cancer Institute

Dr. Wendy Huss joined the Roswell Park Cancer Institute (RPCI) in 2005 as Assistant Professor in the Department of Urologic Oncology. In 2008 she joined the Department of Pharmacology & Therapeutics.

Dr. Huss earned her doctoral degree in Molecular and Cellular Biology from Baylor College of Medicine, Houston, TX, in 2001 and completed a postdoctoral fellowship in the Department of Pathology and Laboratory Medicine from the University of North Carolina.

Dr. Huss has demonstrated ABCG2-mediated efflux of androgen in putative prostate stem cells and her research interests include the role of androgen regulation of prostate stem cells and targeting the malignant prostate stem cell as a source of recurrent prostate cancer.

Select Publications: 

Mathew G, Timm EA Jr, Sotomayor P, Godoy A, Montecinos VP, Smith GJ, Huss WJ. ABCG2-mediated DyeCycle Violet efflux defined side population in benign and malignant prostate. Cell Cycle. 2009 Apr 1;8(7):1053-61.

Sotomayor P, Godoy A, Smith GJ, Huss WJ. Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate. 2009 Mar 1;69(4):401-10.

Godoy A, Watts A, Sotomayor P, Montecinos VP, Huss WJ, Onate SA, Smith GJ. Androgen receptor is causally involved in the homeostasis of the human prostate endothelial cell. Endocrinology. 2008 Jun;149(6):2959-69.

Huss WJ, Gray DR, Tavakoli K, Marmillion ME, Durham LE, Johnson MA, Greenberg NM, Smith GJ. Origin of androgen-insensitive poorly differentiated tumors in the transgenic adenocarcinoma of mouse prostate model. Neoplasia. 2007 Nov;9(11):938-50.

Huss WJ, Gray DR, Greenberg NM, Mohler JL, Smith GJ. Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells. Cancer Res. 2005 Aug 1;65(15):6640-50.

Wu GJ, Fu P, Chiang CF, Huss WJ, Greenberg NM, Wu MW. Increased expression of MUC18 correlates with the metastatic progression of mouse prostate adenocarcinoma in the TRAMP model. J Urol. 2005 May;173(5):1778-83.

Huss WJ, Gregory CW, Smith GJ. Neuroendocrine cell differentiation in the CWR22 human prostate cancer xenograft: association with tumor cell proliferation prior to recurrence. Prostate. 2004 Jul 1;60(2):91-7.

Huss WJ, Gray DR, Werdin ES, Funkhouser WK Jr, Smith GJ. Evidence of pluripotent human prostate stem cells in a human prostate primary xenograft model. Prostate. 2004 Jul 1;60(2):77-90.