Dr. Christiano has initiated a comprehensive program of cellular transplantation and reprogramming that holds great promise toward advancing the feasibility of successfully treating a broad spectrum of disorders of the skin, as well as providing a source of easily accessible multipotent adult stem cells to regenerate other organs. Her lab will exploit the inductive properties of adult hair follicle dermal cells combined with 3D culture and tissue engineered scaffolds to induce new hair follicles. The lab will use adult hair follicle epidermal stem cells and hair follicle dermal stem cells to create a skin equivalent that leads to scarless wound healing.
Bazzi, H., Getz, A., Mahone, M.G., Ishida-Yamamoto, A., Langbein, L., Wahl, J.K. and Christiano, A.M. (2006). Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle. Differentiation 2006; 74:129-140.
Bazzi, H., Martinez-Mir, A., Kljuic, A. and Christiano, A.M. (2005). Desmoglein 4 mutations underlie localized autosomal recessive hypotrichosis in humans, mice and rats. Invest Dermatol Symp Proc 2005; 10:22-24.
O'Shaughnessy, R.F.L., Yeo, W., Gautier, J., Jahoda, C.A.B., Christiano, A.M. The WNT signaling modulator, Wise, is expressed in an interaction-dependent manner during hair follicle cycling. J. Invest. Dermatol. 2004;123:613-621.